2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-114247
    FMAU
    		99.04%
    FMAU is a nucleoside analog and cell proliferation marker that can be phosphorylated by human thymidine kinase and subsequently incorporated into DNA. FMAU is applicable to research related to herpes simplex virus infection, various cancers, hepatitis B virus infection, and Epstein-Barr virus infection.
    FMAU
  • HY-160428
    DMTr-5-fluoro-2'-deoxycytidine-phosphoramidite
    DMTr-5-fluoro-2'-deoxycytidine-phosphoramidite (compound 1B) is a phosphoramidite of 5-Fluoro-2'-deoxycytidine.
    DMTr-5-fluoro-2'-deoxycytidine-phosphoramidite
  • HY-111645R
    3-Methylcytidine (Standard)
    3-Methylcytidine (Standard) is the analytical standard of 3-Methylcytidine. This product is intended for research and analytical applications. 3-Methylcytidine, a urinary nucleoside, can be used as a biomarker of four different types of cancer: lung cancer, gastric cancer, colon cancer, and breast cancer.
    3-Methylcytidine (Standard)
  • HY-400730
    2'-O-POM-rA(Bz)
    		99.31%
    2'-O-POM-rA(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-O-POM-rA(Bz)
  • HY-180594
    3α,7α-Dihydroxycoprostane
    		99.96%
    3α,7α-Dihydroxycoprostane is a metabolite of cholest-4-en-3-one-7α-ol.
    3α,7α-Dihydroxycoprostane
  • HY-W013260R
    2'-O-Methylguanosine (Standard)
    2'-O-Methylguanosine (Standard) is the analytical standard of 2'-O-Methylguanosine (HY-W013260). This product is intended for research and analytical applications. 2'-O-Methylguanosine is a modified nucleoside produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase. 2'-O-Methylguanosine results in apoptotic changes of cells.
    2'-O-Methylguanosine (Standard)
  • HY-148169
    2'-Deoxy-L-guanosine
    		99.30%
    2'-Deoxy-L-guanosine selectively inhibits D-Thymidine phosphorylation catalyzed by HSV 1 thymidine kinase. 2'-Deoxy-L-guanosine is the L-configuration of 2'-Deoxyguanosine (HY-17563).
    2'-Deoxy-L-guanosine
  • HY-200314
    DMTr-2'-O-C22-rU-3'-CE-phosphoramidite
    DMTr-2'-O-C22-rU-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-C22-rU-3'-CE-phosphoramidite
  • HY-116887R
    N6-Methyladenine (Standard)
    N6-Methyladenine (Standard) is the analytical standard of N6-Methyladenine (HY-116887). This product is intended for research and analytical applications. N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication. N6-Methyladenine can be used for the kidney diseases.
    N6-Methyladenine (Standard)
  • HY-W048495
    2'-O-(2-Methoxyethyl)-uridine
    		99.46%
    2'-O-(2-Methoxyethyl)-uridine is a synthetic oligonucleotide conversed from uridine. 2'-O-(2-Methoxyethyl)-uridine has the potential for chemotherapeutic agents development.
    2'-O-(2-Methoxyethyl)-uridine
  • HY-177979
    DNA-GAG
    		Substrate
    DNA-GAG is a slow substrate for Ricin toxin A-chain (RTA). RTA depurinates a single adenylate on a GAGA stem-loop region of eukaryotic 28S RNA, making it a potent toxin.
    DNA-GAG
  • HY-W416297
    dUDP disodium
    dUDP disodium is a nucleotide that plays a crucial role in the synthesis of DNA. dUDP disodium consists of a uracil base, a ribose, and two phosphate groups. dUDP disodium is also a substrate for the deoxyuridine triphosphate nucleotide hydrolase, which catalyzes the conversion of dUDP to dUMP, which is the precursor for dTTP synthesis. dUDP disodium is involved in various biochemical processes and can be used for various biochemical analyses and applications.
    dUDP disodium
  • HY-17026S
    Gemcitabine-13C,15N2
    		99.23%
    antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.
    Gemcitabine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-152513
    2’-O-Methyl-4-thiouridine
    		99.38%
    2’-O-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-O-Methyl-4-thiouridine
  • HY-W009538R
    5'-Deoxy-5-fluorocytidine (Standard)
    5'-Deoxy-5-fluorocytidine (Standard) is the analytical standard of 5'-Deoxy-5-fluorocytidine (HY-W009538). This product is intended for research and analytical applications. 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
    5'-Deoxy-5-fluorocytidine (Standard)
  • HY-138615S5
    Deoxythymidine-5'-triphosphate-d15 dilithium
    Deoxythymidine-5'-triphosphate-d15 (dTTP-d15) dilithium is the deuterium labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.
    Deoxythymidine-5'-triphosphate-d<sub>15</sub> dilithium
  • HY-147412
    Ultevursen
    Ultevursen (QR-421a) is a splice-modulating antisense oligonucleotide targeting exon 13 of the USH2A gene, which restores the functional expression of Usherin protein by inducing exon skipping. Ultevursen binds to USH2A pre-mRNA and modulates the splicing process to specifically skip exon 13 carrying the pathogenic mutation c.2299delG, generating an in-frame transcript and a truncated yet functionally normal protein. Ultevursen exhibits concentration-dependent exon skipping activity in human cells and retinal organoid models, and restores Usherin expression and retinal function in zebrafish and gene-edited mouse models. Ultevursen can be used for related research on type 2 Usher syndrome and non-syndromic retinitis pigmentosa.
    Ultevursen
  • HY-W048479
    7-Iodo-2',3'-dideoxy-7-deaza-guanosine
    		99.17%
    7-Iodo-2',3'-dideoxy-7-deaza-guanosine is a dideoxynucleoside that can be used in DNA synthesis and sequencing reactions.
    7-Iodo-2',3'-dideoxy-7-deaza-guanosine
  • HY-154170
    2',3',5'-Tri-O-acetyl-2-thiouridine
    		99.27%
    2',3',5'-Tri-O-acetyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2',3',5'-Tri-O-acetyl-2-thiouridine
  • HY-152812
    2-Chloro-2′-β-C-methyladenosine
    		99.91%
    2-Chloro-2′-β-C-methyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2-Chloro-2′-β-C-methyladenosine